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Researchers at Lund University in Sweden have been able to show that mice carrying a mutation in the Helicobacter pylori (H. pylori) bacteria have more severe respiratory infections that may be transmitted through the nasal passages of the animals as compared to normal mice. The results point to new possibilities for the treatment of respiratory infections of people suffering from chronic obstructive pulmonary disease (COPD) and COVID-19.
Our results show that mice carrying a mutation in the H. pylori cell surface receptor (HPR) gene have more severe infections than those carrying the mutation without the receptor in their lungs says Samuli Siviainen researcher at the Department of Environmental Medicine Surgeon and Professor at Lund University and the study group leader. We have also treated mice with a substance that prevents the secretion of lipids from the H. pylori cells something that has previously not been possible.
If the results in the study can be translated into humans it is hoped that the effects will be spread by sharing the targeted pathogen-specific therapeutic.
Cold Spring Harbor Laboratory (CSHL) researcher Samuli Siviainen together with her research group has established the model in mice in The Woodlands World Health Organisations collaboration on COVID-19 Respiratory infections.
In early phase 2 clinical trials conducted in South Korea we saw significant differences in the outcome in these mice compared to mice with a similar or positive H. pylori mutation in their lungs explains decades librarian and neurosurgeon Junhee Park of the Center for Disease Control and Preventions National Center for Immunobiology and Microbiology Research (NCIDM).
The reason why may be related to a new functional impairment that hampers Wnt initiation and stimulates lung growth by the eyes says former recipient of the prestigious Nobel Prize in Physiology or Medicine (NS) last year Hyunsoo Kim corresponding author on the study.
Mice with this impairment showed reduced likelihood of infection and inflammation and no increase in bacterial resistance levels when compared to normal mice.