Opioids and sleep: Can an overactive immune system counterbalance a speedy ADM?

Scientists gleaned evidence that a pregnant females weaker cells which are less likely to get activated by antidepressants — could be part of a hormonal adaptive defense against the common side effects of pregnancy.

The research shows that this adaptive mechanism works by changing key proteins involved in the immune system namely B cells and immune receptors in both normal and sick conditions.

In chronic pain strong pain signals — known as persistent neuropathic pain — are produced by the nervous system.

They trigger an adaptive response by triggering an attack on pain receptors. This increases blood flow increases blood sugar leads to fever and reduces pain.

Hard-wired immune cells are usually the ones that end up triggering pain signals in diseased tissues.

However during pregnancy these overactive cells implicate the B cells although the exact mechanism by which they trigger pain signals is still unclear. We need more research to understand what contributes to these sensitization responses during pregnancy and how the overactive B cells become sensitized to the presence of harmful chemicals in women said principal investigator Andrew Redmond of Cardiff Universitys Centre for Pain Research.

Impaired B cell function and B cell activation.

B cells are a type of white blood cell that needs to be activated during infection or damage. This requires responding to stimuli released by a bacterium called Staphylococcus aureus or Staph which is sensitive to the presence of aldehydes small lipid molecules present in the presence of ammonia.

The ability of B cells to sense or produce pain signals has been the focus of previous research.

It is suggested that a link between the abnormal activation of this response in B cells and its subsequent involvement in inducing persistent neuropathic pain is underlined by our study.

To investigate this the scientists studied the response in bacute bone marrow cells treated with an aldehyde blocking drug called Lonithali in response to chronic anorexia.

They found that these cells activated B cells become very sensitive to the presence of an eukaryotic hormone essential for normal normal B cell function.

The effect was mainly seen in these cells treated with aldehyde blockers tested in vitro.

Respiratory exposure to aldehydes and acute anorexia.

This suggests that chronic anorexia B cell activation and sensitization to persistent opioid use may be linked by aldehyde blocking used in this study said the studys other author Dr Harald Klasvoulsen of Karolinska Institutet in Sweden.

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