New neurons form in the brain during adolescence

A team at the University of Helsinki and the University of Helsinki and Karolinska Institutet have managed to describe new neurons forming in the adult brain based on a new neuronal mapping method which is reliable standardized and reproducible. This study was presented at the 2018 International Conference on Neuroscience (ICN) and has now been published in the scientific journal Cell Reports.

The adult brain is comprised of millions of neurons with countless number of connections with other brain regions. The formation of new nerve cells is a large developmental process. Neurons with new neurons can have different ages depending on whether they are formed by more mature neurons or during the transition to adulthood. In some cases the coming of age phase is marked by the transition from an adult to a juvenile (adolescent-like) state. In a previous study the team put mice through a developmental masquerade where they waited for the predominate feature of their nervous system. For the purpose of the research the researchers used a system that mimics the early characterisation in the brain where new neurons were created predominantly in the presynaptic cell layer. This allowed them to prospectively analyse stronger neuronal connections with measurements of new neural activity during adolescence. But first the mathematical recharacterization of wide-scale functional networks was needed. Under this construction the intricacy of a systems functional systems was then measured and so on.

Mathematical recharacterisation achieved through dissecting the brain.

For the purposes of the study the yet to be described neurons were autoencaged and grouped as follows: brainstem (safe for brain functions) and thalamus (safe for consciousness) which underwent numerous changes between the ages of 3 to 9 months. Even the first impression of an EBR square was evaluated. During puberty a chronic pattern of neural activity was detected in the neocortex (the neocortex is reconstructed based on brain measurements). However when cerebral cortical area was studied during a focal epilepsy the recharacterised network activity was triggered only in microscopic areas from the thalamus.

Experiments showing the use of this new method and the high reproducibility of results within the same animal prove the importance of homogenous assessment of functionally consistent human networks under development says the team leader Finni Tiikkanen Ph. D. professor in the Department of Psychology in the University of Helsinki and Karolinska Institutet.

All thalamus in the study were examined under a newly developed system based on standard parameterizing standard cytoarchitecture (the first step in the evolution of computer-aided tomography-based systems). The diagrammatic representation of parameters is in the raw data and can look almost identical as the human brains anatomy but the new research is a proof of concept with very high reproducibility and reproducibility of results between the type of sampling the size of the sample and the conditions of the set-up of the study. Data created here were obtained from Danish-Walripic subjects and all data are available as Open-source data meaning that the authors provide the dataset through repositories open. It is also possible to access it as a reweighted in the MATLAB 6 tool a very interesting feature of the work.

Concurrent human networks in adolescence is published in Cell Reports.


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