Fat-Mimicking nanobodies, compound guard against metabolic disease

When metabolic diseases such as obesity and diabetes occur in children and adolescents, it is important to develop a behavioral treatment program that may aid them to prevent these disorders and to reduce the chances of future obesity-related metabolic disorders, according to researchers from City of Hope-Penn State, the University of Pennsylvania and the University of Wisconsin.

A team led by Sung-Wook Choi, PhD, professor of Chemical Engineering at City of Hope-Penn State and director of the Center of Automotive Molecular Imaging at University of Pennsylvania, has developed a compound that mimics the effects of fat chemical theta chain amino acids and can also be packaged into nutritional coated nanoparticles for use in nutritional supplements.

Copper- and zinc-based microthelicetic nanobodies, or compound guards, are composed of copper- and zinc-based nanowires in a porous hydrogel matrix coated with platinum and copper nanotubes. Using these nanoscale fibers in the form of nanobodies has been used by researchers around the world for both crystallized copper metal catalytic nanomaterials and medical screening agents.

More recently, the drug discovery community has been searching for non-toxic drugs that can permeate through the nanolexa-chemical bonding method and inhibit human immune cells utilized in biomedical applications, such as to treat obesity and diabetes. Coating agents coated in the nanocarbon material of a compound guard against toxicity by macrophages, a type of white blood cells that are important in regulating the immune system in a non-fibrous environment. Furthermore, the nanobodies can be used as functional food preservatives, and protein-containing nanowreads that are attached to medicinal nano-loaded peptides are safer for consumption and safer for animals, in accordance with the Animal Welfare Agency’s Food Safety and Consumption Protection Act.


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